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"By contrast, the Nav1.6 blocker 4,9-ahTTX strongly decreased I NaP in amplitude and shifted toward more depolarized values its voltage activation threshold without modifying the half-activation potent[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"We observed SWD in mice carrying three alleles : Scn8a 8 J, a new allele with a non conservative amino acid substitution in the pore region of the channel and the well characterized mutations Scn8a med, a null allele, and Scn8a med-jo, a missense mutation in an intracellular linker that causes altered voltage dependence."