IndraLab

Statements

reach
"ICA strongly inhibits inactivation and thereby increases the magnitude of hERG1 channel currents, especially at positive potentials."
22930803
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"The hERG activator ICA‐105574 shows structural similarities with LUF7244 and has been analysed in anaesthetized dogs at 1 and 10 mg·"
31339551
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"The same concatenation strategy used to characterize PD was used to study ICA, a compound which enhances hERG1 current by strongly inhibiting channel inactivation."
24638994
reach
"ICA increases the magnitude of outward hERG1 currents by profound attenuation of inactivation."
24638994
reach
"We took advantage of our previous finding that L646E and F557L mutations nearly abolish the ability of PD and ICA, respectively, to enhance hERG1 currents."
24638994