IndraLab

Statements

reach
"The knockout of USP22 in pancreatic ductal adenocarcinoma cells results in reduced myeloid cells infiltration and increased tumor infiltration of NK cells and T cells, leading to a synergistic response with combined immunotherapy (59)."
37415977
reach
"Increased infiltration of NK cells within the TME is a favorable prognostic factor in several solid tumors [35]; however, USP22 has been reported to suppress NK cell infiltration by altering the transcriptome of pancreatic cancer (PC) cells [36]."
38715050
reach
"Inhibiting USP22 would lead to less activation of immune cells to immunosuppressive microenvironment or more infiltration of immune cells to immune-sensitive status, this issue of deeply associated mechanisms needs to consistently be solved."
37658402
reach
"USP22 in PC cells interacts with SAGA/STAGA to affect the immune microenvironment, and USP22 deficiency promotes T-cell and NK cell infiltration and inhibits tumor metastasis (116)."
37529035
reach
"We report that deletion of USP22 in pancreatic tumor cells reduced the infiltration of myeloid cells and promoted the infiltration of T cells and NK cells, leading to an improved response to combination immunotherapy."
31871120
reach
"The decreased expression of the deubiquitinase USP22 in pancreatic cancer cells promoted the infiltration of natural killer and T cells, thereby enhancing the anti-tumor immune response of the TME.91 Ubiquitination modification also regulates T cells to promote the differentiation of other cells."
39759114
reach
"In mouse models of hepatocellular carcinoma, knockout of Usp22 increases the infiltration of tumor-infiltrating lymphocytes, augments anti-tumor immunity, and synergizes with anti-PD-L1 treatments and chemotherapy (29)."
37415977
reach
"Tumor cell-derived CXCL1 and ubiquitin-specific protease 22 (USP22) were shown to decrease T cell infiltration and response to immunotherapy in PDAC."
35127250