IndraLab

Statements

P5091 activates USP7. 4 / 4
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"The USP7 inhibitors, HBX 19,818 and P5091, were previously reported to selectively inhibit USP7 in vitro and in vivo, and importantly, P5091 showed cytotoxicity in relapsed MM cells derived from cancer patients (Chauhan et al., 2012; Reverdy et al., 2012)."
30486612
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"At present, a variety of small molecular inhibitors, natural compounds and small molecular peptides against USP7 have shown specific USP7 inhibition and certain anti-tumor activity [20], such as USP7 inhibitor P5091 [28], which can reduce Wnt signal pathway activity by enhancing ubiquitin-mediated degradation of β-catenin.c-Myc plays a pivotal role in the Warburg effect."
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"These inhibitors, and particularly P5091 and P22077, have been shown to induce degradation of many USP7 substrates and phenocopy USP7 knockdown."
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"Another USP7 inhibitor, P5091 selectively inhibits USP7 both in vitro and in vivo 89."
27002218