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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

HCRT increases the amount of ATXN3. 2 / 2

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"In the orexin and ataxin -3 transgenic mouse model, the HCRT promoter drives expression of the polyglutamine neurodegenerative ataxin-3 protein, resulting in a postnatal loss of Hcrt neurons."

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"XREF_BIBR In these mice, the orexin promoter drives expression of the neurodegenerative gene ataxin-3, leading to progressive loss of the orexin neurons during development."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...