IndraLab

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HCRT increases the amount of ATXN3. 2 / 2

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"In the orexin and ataxin -3 transgenic mouse model, the HCRT promoter drives expression of the polyglutamine neurodegenerative ataxin-3 protein, resulting in a postnatal loss of Hcrt neurons."

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"XREF_BIBR In these mice, the orexin promoter drives expression of the neurodegenerative gene ataxin-3, leading to progressive loss of the orexin neurons during development."

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IndraLab

Statements

HCRT increases the amount of ATXN3. 2 / 2

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