IndraLab

Statements


USP25 inhibits FOXP3. 4 / 4
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"Our results demonstrate how USP21 prevents FOXP3 protein depletion and controls Treg lineage stability in vivo."

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"Therefore, these results support that USP21 prevents FOXP3 depletion in Treg cells through deubiquitination and protection from ubiquitination mediated protein degradation."

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"Here we report that the E3 deubiquitinase USP21 prevents the depletion of FOXP3 at the protein level and restricts the generation of T-helper-1-like Treg cells."

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"Taken together, our results show that USP21 prevents FOXP3 protein depletion and controls Treg lineage stability in vivo."