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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine decreases the amount of USP9X. 3 / 3

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"Taken together, BIX-01294 decreases the expression of USP9X and promotes the degradation of MCL1, which eventually leads to apoptosis in bladder cancer cells."

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"We found that BIX-01294 reduced the level of USP9X in the dose- and time dependent manner, and MCL1 was degraded more in USP9X siRNA knockdown cells compared with the Control siRNA knockdown cells."

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"We found that BIX-01294 up-regulated the expression of PMAIP1 and down-regulated the level of MCL1 and USP9X."

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6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine decreases the amount of USP9X. 3 / 3

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