IndraLab

Statements

RUNX1 increases the amount of USP15. 3 / 3
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reach
"This study investigated PH-related molecular interactions in PASMCs and found: 1) RUNX1 promotes hypoxia-induced PASMC dysfunction and PH; 2) RUNX1 transcriptionally activates the expression of USP15; 3) USP15 reduces CBX5 ubiquitination and promotes CBX5 expression; and 4) RUNX1 regulates PASMC function through the USP15/CBX5 axis.RUNX1 is a master developmental regulator essential for hematopoietic cell differentiation and normal hematopoiesis [21]."
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reach
"By binding to the USP15 promoter, RUNX1 increased USP15 transcription and promoted USP15 expression in PASMCs.USP15 belongs to the USP family of deubiquitinating enzymes that mediate the reverse process of ubiquitination, called deubiquitination."
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reach
"In summary, RUNX1 stimulates hypoxia-induced PASMC dysfunction by increasing USP15 transcription to promote the deubiquitination and expression of CBX5."
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