IndraLab

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USP10 deubiquitinates Histone. 3 / 3
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"USP10 deubiquitylates the histone variant H2A.Z and both are required for androgen receptor mediated gene activation."
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"Moreover, USP10 not only binds AR, resulting in increased transcriptional activity, but also deubiquitinates the histone variant H2A.Z, both of which are required for AR - mediated gene activation [XREF_BIBR, XREF_BIBR]."
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"In addition, more bulky structures, SUMO (small ubiquitin related modifier) and ubiquitin are conjugated to histones (Galanty et al., 2009; Morris et al., 2009; Shioo and Eisenman, 2003; Thakar et al.[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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