IndraLab

Statements

TEA activates KCNB1. 3 / 3
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"Although internal TEA slows deactivation of WT Kv2.1 (Extended Data Fig. 4d,e), it has no discernible effect on the similar OFF gating currents measured in F412L (Fig. 4b,c), suggesting that the internal pore of F412L remains closed to the blocker."
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"As predicted from block of whole-oocyte currents, internal TEA produced a slow block of DRK1 and RCK2 single-channel currents but had almost no effect on r-NGK2 single-channel currents."
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"Both Kv2.1 and BK-channels are blocked by the broad-spectrum K + -channel blocker TEA ( Bokvist et al., 1990a, 1990b; Fatherazi and Cook, 1991 )."
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