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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

MDM2-C462A inhibits TP53. 1 / 1

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"Here, we show in vivo that the Mdm2 (C462A) protein not only fails to suppress p53, but compared to the complete absence of Mdm2, Mdm2 (C462A) actually enhances p53 transcriptional activity toward p53 target genes p21 and CDKN1A, MDM2, BAX, NOXA, and 14-3-3sigma."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...