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MDM2-C462A inhibits TP53. 3 / 3
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"In the presence of 4-OHT, p53 was decreased in the Mdm2 +/+ ;p53 ER/− MEFs, due to expression of Mdm2, but was unchanged or slightly increased in the Mdm2 C462A/C462A ;p53 ER/− MEFs ( Figure 3 A, p53 [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Even when expressed at a very high level in the Mdm2 C462A/C462A ;p53 ER/− MEFs upon 4-OHT induction, the mutant Mdm2 C462A , unlike wild-type Mdm2, cannot suppress p53 activity, at least toward p21 a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"We therefore investigated whether the embryonic lethality of Mdm2 C462A/C462A mice was also due to the inability of the mutant Mdm2 to suppress p53."
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