IndraLab
Statements
sparser
"Positive regulators of emmprin expression include amphiregulin and EGF-EGFR interactions [ xref ], and negative regulators include Pinin, a nuclear and cell adhesion-related protein [ xref ], and Caveolin-1 which reduces emmprin glycosylation and associated MMP activity [ xref ]."
sparser
"For example, the concomitant presence of the epidermal growth factor receptor (EGFR) and its ligands EGF and amphiregulin is associated with enhanced tumor aggressiveness and shorter survival in patients. xref K-ras proto-oncogene and mutations of the p53 tumor-suppressor gene and the Smad4 gene are frequently dysregulated in the tumors."