IndraLab

Statements

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"YTHDF1 could promote the translation of USP14 protein, which then promoted the tumorigenesis and metastasis of GC (109, 137)."
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"It has been shown that USP14 induces PI3K/Akt signaling to enhance growth and metastasis of HCC."
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"USP14 promoted pancreatic tumour growth and metastasis."
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"Collectively, these data revealed that the overexpression of USP14 promoted HNSCC proliferation and metastasis and decreased cell apoptosis in vitro."
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"In vitro and in vivo functional experiments confirmed that USP14 was a driver of cancer progression and liver metastasis in PDAC."
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"Additionally, we found that administration of a USP14-specific inhibitor, IU1, prevented PDAC progression and liver metastasis in mouse models."
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"USP14 Deficiency Represses Tumor Growth and Lung Metastasis In Vivo."
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"However, whether USP14 contributed to PDAC progression and metastasis in animal models and the identity of the precise mechanism remained unknown."
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"USP14 promotes the proliferation and metastasis of HNSCC in vivo and in vitro."
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"Ubiquitin specific protease 14 (USP14) promotes proliferation and metastasis in pancreatic ductal adenocarcinoma."
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"However, the precise role and mechanisms of BACH1 in ovarian cancer remain largely unclear.Here, we demonstrate that BACH1 functions as a substrate protein of USP14, which regulates heme metabolism an[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Taken together, these data revealed that USP14 depletion inhibited HNSCC proliferation and metastasis and increased HNSCC apoptosis in vitro."
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"165 Lactation of lysine has recently been identified in liver cancer, which occurs mainly on two tumor‐associated proteins, USP14 and ABCF1, which promote the development of liver cancer and lung metastasis."
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"In contrast, studies using OSCC cells have demonstrated that TGF-beta signals can mediate Epithelial- mesenchymal transitions, further contributing to cancer cells migration and invasion (Meng et al.,[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In addition, depletion of USP14 led to proteasome-dependent degradation of TAZ and ultimately arrested PDAC tumour growth and liver metastasis."
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"11 In addition, USP14 reportedly regulates the expression of downstream target genes of TAZ through a feedback mechanism and ultimately promotes pancreatic ductal adenocarcinoma tumor progression and liver metastasis."
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"Collectively, we uncovered that hyperactive USP14 contributed to HNSCC tumor growth and lung metastasis by reinforcing HSF1-depedent HSP activation, and our findings provided the insight that targeting USP14 could be a promising prognostic and therapeutic strategy for HSNCC."
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"30 Overall, these data suggest that increased expression of Usp14 may enhance beta-catenin-mediated transformation of normal colon cells, but not metastasis of malignant colon cancer cells."
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"The results showed that depletion of USP14 decreased the number of micrometastases and increased the OS of mouse, while overexpression of USP14 led to a significant increase in liver metastasis and reduced the OS time of the mice (Fig. 5C–E, H–J)."
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"We also demonstrated that USP14 increased HNSCC cell proliferation and metastasis."
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"Taken together, these results indicated that USP14 promoted PDAC proliferation and metastasis in a TAZ signalling-dependent manner."
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