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USP4 inhibits MYOD1. 4 / 4
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"When MyoD activity was monitored by means of a luciferase reporter, it was revealed that the USP4 knockdown increased the MyoD activity, as compared to the control (MyoD + siUSP4 vs. MyoD; Fig. 2 A )."
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"Conversely, USP4 overexpression decreased the MyoD activity as compared to the control (MyoD + USP4 vs. MyoD; Fig. 2 B), and accordingly the effect of SAHA and MC1568 on MyoD activity was attenuated b[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The role of USP4 in many pathological and physiological processes has been reported; USP4 promotes breast cancer invasive migration through the relaxin2-mediated TGF-β1/Smad2/MMP-9 pathway [31]; USP4 inhibits myogenic cell differentiation by catalyzing MyoD activity [32]; The H19/miR-148a/USP4 axis promotes hepatic stellate cells by enhancing and TGF-β signaling in hepatocytes to promote liver fibrosis [33]."
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"For instance, the deubiquitinase ubiquitin‐specific protease 4 (USP4) has been shown to suppress MyoD activity in a catalytic activity independent manner."
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