IndraLab

Statements

GUK1 activates KCNMA1. 2 / 2
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"The guanylate kinase domain of Ca (v) beta1 mediates Slo1 regulation through its binding to calcium bowl domains, and this domain of Ca (v) beta1 is necessary and sufficient for the observed effects on BK (Ca) activation."
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"Several of these genes are required for extended egl-30(gf) memory, including slo-1/Kcnma1, the α subunit of a calcium-activated BK channel; madd-4/Adamtsl1, which is involved in axon guidance and synapse organization; unc-73/Kalrn, a known downstream target of G signaling, and magi-1/Magi2, a membrane-associated guanylate kinase homolog (MAGUK) family member involved in habituation and long-term memory."
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