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Nicotine decreases the amount of OTUD3. 2 / 2
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"For instance, nicotine has been shown to increase VEGF-C levels in ESCC and influence lymphatic metastasis by reducing the expression of OTUD3, thereby inhibiting the ability of ZEP36 to bind to specific regions of VEGF-C mRNA and causing its decline (77)."
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"Downregulation of OTUD3 expression by Nicotine in esophageal cancer leads to downregulation of ZFP36, which induces VEGF-C production and promotes lymphatic metastasis in esophageal cancer (Wang et al., 2021) (Figure 2D)."
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