IndraLab

Statements


BAP1 deubiquitinates ITPR3. 3 / 3
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"We hypothesized that BAP1 might deubiquitylate and stabilize IP3R3."

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"At the ER, BAP1-dependent deubiquitination of the type 3 inositol-1,4,5-trisphosphate receptor (IP3R3) is necessary to sustain the IP3R3 ER channel integrity (11,55)."

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"Along with maintenance of IP3R3 ER channel integrity, BAP1-dependent deubiquitination of IP3R3 may change the threshold for IP3R3 activation by Ca itself or IP3."