IndraLab

Statements

BAP1 deubiquitinates ITPR3. 7 / 7
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"We hypothesized that BAP1 might deubiquitylate and stabilize IP3R3."
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"For example, BAP1 promotes apoptosis by deubiquitinating and stabilizing IP3R3 at the endoplasmic reticulum (ER), which stimulates Ca release from the ER into the cytosol and thereby increases the mitochondrial Ca concentration and cytochrome C release ."
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"BAP1 can regulate Ca release from the ER to the cytoplasm and mitochondria to promote cell apoptosis by binding, deubiquitylating and stabilizing IP3R3 [45]."
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"At the ER, BAP1-dependent deubiquitination of the type 3 inositol-1,4,5-trisphosphate receptor (IP3R3) is necessary to sustain the IP3R3 ER channel integrity (11,55)."
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"Along with maintenance of IP3R3 ER channel integrity, BAP1-dependent deubiquitination of IP3R3 may change the threshold for IP3R3 activation by Ca itself or IP3."
33446574
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"BAP1 regulates Ca release from endoplasmic reticulum and mitochondria by deubiquitinating and stabilizing inositol 1,4,5-trisphosphate receptor type 3 (IP3R3), promoting apoptosis after genotoxic stress (14)."
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"The endoplasmic reticulum (ER) fraction is the primary location of cytoplasmic BAP1, where it deubiquitylates and stabilizes the type 3 inositol-1,4,5-trisphosphate receptor (IP3R3)."
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