IndraLab

Statements

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"In summary, in vitro assays indicated that USP11 enhances CRC cell proliferation, migration, and invasion, but showed no effect on apoptosis.3.3 USP11 enhances tumorigenesis and liver metastasis of CRC in vivo."
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"Conversely, depletion of USP11 inhibited H1299 cell proliferation and induced ferroptosis [143]."
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"Namely, USP11 has been shown to promote the proliferation and metastasis of hepatocellular carcinoma (HCC), but the underlying molecular basis is poorly understood."
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"Consistent with the rescue of NOTCH1 expression, ectopic expression of the USP11 WT, but not of the catalytically inactive form of USP11, partially rescued the proliferation inhibition induced by silencing of USP11 in T-ALL cells (Fig. 2H, and Supplementary Fig. 1)."
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"Functionally, USP11 mediated melanoma cell proliferation via the regulation of NONO levels because ablation of USP11 inhibits the proliferation which could be rescued by ectopic expression of NONO protein."
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"To investigate whether PPP1CA affects the oncogenic roles of USP11 in CRC, we used CCK-8 and transwell assays to investigate the effects of PPP1CA on USP11-promoted proliferation and migration of CRC cell lines."
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"We also demonstrated that USP11 promoted the melanoma cells proliferation and tumorigenesis via NONO."
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"Conversely, knockdown of PPP1CA could also partially decrease the effects of overexpression of USP11-promoted cell proliferation and migration in HCT8 cells."
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"Depletion of USP11 inhibits cell proliferation and induces ROS-mediated stress-induced ferroptosis, an effect that can be mitigated by overexpression of NRF2."
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"Furthermore, these promoting effects on cell proliferation and migration caused by increased expression of USP11 or PPP1CA could be weakened by the ERK1/2 inhibitor, SCH772984 (Selleck, Cat."
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"Functionally, USP11-mediated stabilization of cytoplasmic p21 induced breast cancer cell proliferation in vitro and in vivo ."
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"Taken together, these results indicate that the E2F1 and USP11 signal axis promotes HCC proliferation and metastasis and inhibits autophagy, which provides an experimental basis for the treatment of HCC."
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"While USP11 is known to promote HCC metastasis and proliferation, the precise mechanisms, especially those related to cancer metabolism, remain unclear."
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"In congruence with previous report, 11 USP11 knockdown inhibited the proliferation of A375, which could be reversed by the introduction of ectopic NONO."
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"We also demonstrated that overexpression of USP11 promoted proliferation and metastasis of CRC cells in vitro and in vivo, indicating that USP11 plays an important role in the development of CRC."
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"3.5 USP11 promotes melanoma cell proliferation via NONO."
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"In the present study, we demonstrated that USP11 could promote the proliferation of CRC cells via CCK8 and colony formation assays in vitro and subcutaneous xenograft assay in vivo."
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"Similar results were yielded from a CCK-8 assay, indicating that USP11 mediated the proliferation of melanoma cells through NONO."
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"11 In congruence with this, our results indicate that USP11 acts as an oncogene, because USP11 overexpression promotes the proliferation of melanoma cells, whereas knockdown of USP11 exhibits the opposite function."
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"Furthermore, we demonstrate that USP11 mediates the proliferation of melanoma cells via NONO because the effect of USP11 knockdown on melanoma cells could be rescued by introducing NONO."
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"Higher levels of USP11 enhance lipogenesis, proliferation, and metastasis in HCC cells."
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"Also, USP11 had been confirmed to accelerate proliferation, invasion and migration in keloid derived-fibroblasts ."
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"USP11 deficiency inhibits lipogenesis and proliferation of HCC cells in vivo and in vitro."
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"For example, the aberrant expression of USP11 was found to interact with nuclear factor 90 and promote its deubiquitination, to promote the proliferation and metastasis of hepatocellular carcinoma."
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"Additionally , USP11 could promote cell proliferation and metastasis via regulating nuclear factor 90 ( NF90 ) in hepatocellular carcinoma [ 37 ] ."
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"It is highly expressed in colorectal cancer, hepatocellular carcinoma and oral cancer, and is considered as an indicator of poor prognosis by activating signaling pathways to promote tumor cell proliferation, invasion and metastasis through changing cell cycle activity USP11 mediates cell proliferation and participates in cell signal transfer pathway."
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"USP11 is highly expressed in non-small cell lung cancer and promotes cell proliferation."
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"In this study, we observed that depleting USP11 inhibits cell proliferation and delays cell cycle progression."
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"USP11 promotes the proliferation, migration, and invasion of CRC cells by modulating IGF2BP3 stability [84]."
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"In general, our results demonstrate that USP11 promotes HCC proliferation and metastasis through HIF-1alpha/LDHA-induced glycolysis, providing new insights and the experimental basis for developing new treatments for this patient population."
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"Weitong Zhang et al. [38] found USP11 promotes the proliferation and migration of colorectal cancer, and the Circ-DOCK1/MiR-132-3p axis further repressed USP11 transcription."
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"The authors postulated that USP11 up-regulates and augments the ability of proliferation, invasion, migration and collagen deposition of keloid-derived fibroblasts (KFBs) through deubiquitinating TGF-β receptor II (TβRII)."
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"USP11 elevates the ability of proliferation, collagen deposition, invasion and migration of keloid-derived fibroblasts by deubiquitinating TβRII."
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"Silencing of USP11 maintained KLF4 stability and repressed proliferation and chemoresistance of HCC cells."
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"Changmao Zhang et al. [88] identified that USP11 promoted the proliferation and metastasis of hepatocellular carcinoma via deubiquitinating NF90, which was also proved to promote the proliferation and angiogenesis of cervical cancer."
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"These findings confirmed that USP11 can modulate HIF‐1α activity.In previous work, we reported that USP11 might increase both HCC cell migration and proliferation, 16 and HIF‐1α has been shown to trigger the transcription of genes involved in HCC proliferation, angiogenesis, metastasis and invasion."
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"Furthermore, Heeyoung Yang et al. [30] identified that USP11 promotes the proliferation, tumorigenesis, and sorafenib-resistance of hepatocellular carcinoma via negatively regulating KLF4, which was known as a tumor suppressor factor in previous researches."
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"We have demonstrated that USP11 silencing suppressed the proliferation and DNA synthesis of human SSCs and enhanced their apoptosis, and we identified HOXC5 as a downstream target of human SSCs."
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"Correspondingly, USP11 knockdown reduced cell proliferation, and HIF‐1α overexpression restored cell proliferation ability to a certain extent (Figure 3D)."
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"On the other hand, USP11 significantly stimulates proliferation and metastasis of hepatocellular carcinoma cells both in vitro and in vivo [34]."
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"USP11 promotes cervical cancer progression and proliferation through deubiquitination and stabilization of HPV-16E7, subsequently affecting the biological function of E7 as well as the HPV-16E7 contribution to cellular transformation [104] (Fig. 4)."
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"36 Combination and deubiquitination of USP11 to nuclear factor 90 (NF90) stabilized the protein expression and promoted HCC cell metastasis and proliferation."
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"Additionally, USP11 could promote cell proliferation and metastasis via regulating nuclear factor 90 (NF90) in hepatocellular carcinoma [XREF_BIBR]."
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"Taken together, these data indicate that USP11 overexpression may be relevant with the tumorigenesis and progression of CRC.3.2 USP11 promotes CRC cell proliferation, migration, and invasion in vitro."
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"Cell Counting Kit 8 (CCK8) assay showed that USP11 knockdown significantly inhibited cell viability and proliferation in HCT116 cells compared with the control group, whereas the opposite effect was observed in USP11-overexpressing HCT8 cells (P "
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