IndraLab

Statements

OLR1 activates SCARB2. 8 / 8
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"CD36 is activated also by oxLDL."
34281247
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"The requirement of TRPM2 for CD36 activation by oxLDL and TSP1 is an unexpected discovery."
35445217
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"To understand the mechanisms by which TRPM2 regulates CD36 activation, we applied BAPTA-AM to chelate intracellular Ca 2+ including the TRPM2-mediated Ca 2+ influx, and found that oxLDL-induced CD36 activation was abolished ( xref , xref )."
35445217
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"In contrast, CD36 signaling activation by oxLDL results in increased cholesterol deposition and nuclear sequestration of AMPK, diminishing β–oxidation ( xref ; xref )."
25801026
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"Another example of a cellular response induced by scavenger receptor is activation of CD36 by OxLDL."
19457577
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"Our findings support a model where oxLDL activates macrophage CD36 and caspase 3/7–dependent microparticle formation, which increases the thrombogenicity of the atheroma core."
32750308
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"Other studies suggest that OxLDL activation of CD36 occurs via engagement of the TLR4/TLR6 heterodimer, but not at the cell surface, in endosomes ( xref )."
23937439
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"We found that TRPM2 is required for CD36 activation and oxLDL uptake in macrophages, and activation of CD36 by oxLDL further promotes the activation of TRPM2, thereby forming a feed-forward viscous cycle [ xref ]."
35159300