IndraLab

"In contrast, CD36 signaling activation by oxLDL results in increased cholesterol deposition and nuclear sequestration of AMPK, diminishing β–oxidation ( xref ; xref )."

"Another example of a cellular response induced by scavenger receptor is activation of CD36 by OxLDL."

"The requirement of TRPM2 for CD36 activation by oxLDL and TSP1 is an unexpected discovery."

"Activation of CD36 by ox-LDL can also trigger ligand-dependent recruitment and activation of nonreceptor tyrosine kinases, specific mitogen-activated protein kinases (MAPKs), and the Vav family of gua[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

"We found that TRPM2 is required for CD36 activation and oxLDL uptake in macrophages, and activation of CD36 by oxLDL further promotes the activation of TRPM2, thereby forming a feed-forward viscous cycle [ xref ]."

"OxLDL activates the scavenger receptor CD36 on the surface of macrophages, triggering the assembly of the NLRP3 inflammasome and promoting the maturation and release of IL-1β ( xref ) Additionally, the upregulation of fatty acid synthase (FASN) in keratinocytes leads to the accumulation of free fatty acids, which enhances IL-23 secretion via the TLR4/MyD88 pathway, thereby activating the IL-17 signaling axis ( xref )."

"We found that the activation of TLRs and CD36 in macrophages by oxLDL promotes the secretion of cytokines and increases the expression of MHC-II and co-stimulatory molecules, such as CD86, which could[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

"To understand the mechanisms by which TRPM2 regulates CD36 activation, we applied BAPTA-AM to chelate intracellular Ca 2+ including the TRPM2-mediated Ca 2+ influx, and found that oxLDL-induced CD36 activation was abolished ( xref , xref )."

"Mechanistic studies have established that oxLDL activates the scavenger receptor CD36 on platelets to upregulate signaling pathways that enhance platelet responses, including reactive oxygen species generation and caspase activation, xref , xref and transduce intracellular signaling through associations among CD36, Syk, and SFKs. xref , xref , xref , xref Studies have also shown that MAPK JNK2 is phosphorylated in platelets exposed to oxLDL mediated by SFKs, which is essential for downstream signaling events and upregulation of ERK5 and MAPK signaling pathways. xref , xref , xref However, it has remained generally unknown how oxLDL activation in combination with other platelet agonists affect protein activity along GPVI/ITAM signaling cascades."

"Our findings support a model where oxLDL activates macrophage CD36 and caspase 3/7–dependent microparticle formation, which increases the thrombogenicity of the atheroma core."

"Moreover, it is reported that the activation of CD36 by oxLDL results in the inhibition of migration of monocytes and macrophages, thus representing a mechanism of cell retention in atherosclerotic pl[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

"Other studies suggest that OxLDL activation of CD36 occurs via engagement of the TLR4/TLR6 heterodimer, but not at the cell surface, in endosomes ( xref )."

"When AS developed into fatty streak stage, β2/aβ2 inhibited oxLDL-induced CD36 activation and subsequently the intracellular lipid accumulation, FAK activation and the reversed-migration of THP-1 macr[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

"These results suggest that oxLDL activates CD36 to induce the production of IL-1β and IL-6."

"CD36 is activated also by oxLDL."