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USP25 increases the amount of APP. 2 / 2

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"The proposed mechanism by which USP25 modifies Aβ deposition is via modification of APP processing; USP25 overexpression in 5XFAD mice increased APP and BACE1 levels while conversely Usp25 deficiency in 5XFAD mice reduced levels of FL-APP, α-CTFs and β-CTFs (Zheng et al., 2022)."

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"We tested whether RNAi mediated knockdown of endogenous USP25 causes a reduction in endogenous APP protein levels."

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IndraLab

Statements

USP25 increases the amount of APP. 2 / 2

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