IndraLab

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USP15 deubiquitinates NFE2L1. 4 / 4
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"Under these experimental conditions, USP15 significantly reduced the smear patterns of 3 x Flag-Nrf1, suggesting that USP15 promotes the deubiquitination of Nrf1."
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"Here, we report that USP15 (Ubiquitin-Specific Protease 15) activates Nrf1 in the nucleus by stabilizing it through deubiquitination."
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"As a result, these data strongly suggest that USP15 stabilizes endogenous NRF1.We further conducted a ubiquitination assay to examine whether USP15 deubiquitinates Nrf1."
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"Taken together, it is fully possible that USP15 deubiquitinates Nrf1 in the nucleus."
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