IndraLab

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USP15 deubiquitinates NFE2L1. 4 / 5
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"Levels of NFE2L1 are also regulated by several deubiquitinating enzymes, including USP7, USP19 (specifically in the ER), and USP15 (in the nucleus), that deubiquitinate NFE2L1 and increase its stability and transcriptional activity [136,137,138]."
37759569
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"As a result, these data strongly suggest that USP15 stabilizes endogenous NRF1.We further conducted a ubiquitination assay to examine whether USP15 deubiquitinates Nrf1."
27416755
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"Under these experimental conditions, USP15 significantly reduced the smear patterns of 3 x Flag-Nrf1, suggesting that USP15 promotes the deubiquitination of Nrf1."
27416755
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"Taken together, it is fully possible that USP15 deubiquitinates Nrf1 in the nucleus."
27416755