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Mutated BAP1 activates Neoplasms. 5 / 5
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"Whereas BAP1 mutations drive BAP1 tumour predisposition syndrome, mesotheliomas, melanomas and other neoplasms 8–11 ; ASXL1 mutations are particularly prevalent in myeloid cancers, and are associated [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Herein, we set out to investigate whether BAP1 mutations could regulate the development in UM, and our results demonstrated that BAP1 mutations could induce the tumor immune microenvironment in UM by inactivating the NF-κB signaling pathway."
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"Moreover, BAP1 mutations may elevate tumor responsiveness to immunotherapy (36)."
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"Cutaneous melanoma, melanocytic tumors and other skin tumors:. The frequency of cutaneous melanoma (CM) development is likely to increase with germline BAP1 mutations and tumor-promoting effects of these BAP1 mutations are strongly influenced by co-occurrence of associated oncogenes such as mutant BRAF (2,43)."
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"For example, mesothelioma cells that carry germline BAP1 mutations have upregulated aerobic glycolysis (17), and BAP1 mutant ccRCC tumor samples display elevated glycolysis (22)."
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