IndraLab

Statements

OTUB1 is phosphorylated on Y26. 23 / 23
| 23
sparser
"IFNγ−mediated OTUB1 phosphorylation at Tyr26 plays a critical role in stabilizing p27."
38664499
sparser
"Since we focused on SHP2-mediated phosphorylation of OTUB1 at Y26, we excluded LYN and ITK, as siRNA of LYN and ITK still dephosphorylated OTUB1 at Y26 in ODN-treated cells (Fig. xref )."
37330581
sparser
"Observing the increased phosphorylation of OTUB1 and p27 expression following IFNγ treatment led us to hypothesize that OTUB1 Tyr26 phosphorylation could regulate p27 stability."
38664499
sparser
"This study showed that cathepsin K inhibition activates SHP2, a tyrosine phosphatase, that dephosphorylates OTUB1 and destabilizes Raptor, whereas SHP2 deletion and pharmacological inhibition increase OTUB1-Y26 phosphorylation and Raptor expression."
37330581
sparser
"These findings suggest that OTUB1 Y26A could serve as a specific and potent site controlling IFNγ-induced p27 expression, emphasizing the crucial role of OTUB1 phosphorylation at Tyr26 in IFNγ-mediated p27 stabilization through deubiquitination."
38664499
sparser
"We further confirmed that Syk and ZAP70 likely affect SHP2-mediated OTUB1-Y26 phosphorylation in cathepsin K siRNA-treated cells."
37330581
sparser
"Our previous findings demonstrated that Src contributes to the phosphorylation of the Tyr26 residue of OTUB1 [ xref ]."
38664499
sparser
"Previous reports suggested that Src kinase plays a major role in OTUB1 phosphorylation at Y26 and Raptor stabilization [ xref ]."
37330581
sparser
"We further investigated the mechanisms involved in ODN-induced inhibition of OTUB1 phosphorylation at Y26."
37330581
sparser
"As previously demonstrated in renal cancer cells, the non-receptor tyrosine kinase Src mediates OTUB1 Tyr26 phosphorylation [ xref ]."
38664499
sparser
"The authors also reported that SRMS induced the phosphorylation of OTUB1 at Y26, which resulted in Raptor stabilization."
37251450
sparser
"Intriguingly, the phosphorylation of OTUB1 at Y26 did not affect the stability of other OTUB1-targeted substrates."
37251450
sparser
"In conclusion, our study highlights the significant role of OTUB1 phosphorylation at Tyr26 in cancer cell cycle arrest by stabilizing p27 expression."
38664499
sparser
"Phosphorylation of OTUB1 at Tyr 26 stabilizes the mTORC1 component, Raptor."
35927303
sparser
"Mutation of SHP2 increased OTUB1 phosphorylation at Y26 thereby inducing Raptor protein expression."
37330581
sparser
"The non-receptor tyrosine kinase Src-mediated phosphorylation of OTUB1-Y26 plays a critical role in Raptor stabilization, whereas cathepsin K inhibitor (odanacatib; ODN) and knockdown (siRNA) induce Raptor destabilization."
37330581
sparser
"Furthermore, non-receptor tyrosine kinases (Src and SRMS kinases) induced phosphorylation of OTUB1 at Y26, which stabilized Raptor."
35927303
sparser
"The phosphorylation of OTUB1 at Tyr26 emerged as a critical factor in IFNγ-induced p27 upregulation."
38664499
sparser
"In kidney cancer patient samples, OTUB1-Y26 phosphorylation is significantly increased and correlates with RAPTOR protein levels."
38264570
sparser
"Interestingly, phosphorylation of OTUB1 at Y26 did not affect the stability of other OTUB1-targeted substrates."
35927303
sparser
"However, the mechanisms involved in cathepsin K inhibition-induced OTUB1-Y26 phosphorylation in Raptor stabilization have not been yet elucidated."
37330581
sparser
"IFNγ upregulates p27 expression and OTUB1 phosphorylation at Tyr26."
38664499
sparser
"Src-mediated OTUB1 phosphorylation at tyrosine 26 residue (Y26) plays an important role in Raptor stabilization [ xref ]."
37330581