IndraLab

Statements

USP9X inhibits SOX2. 2 / 2
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"Usp9x KD blocked the induction of SOX2 by vemurafenib or MEKi treatment in melanoma cell lines with mutant BRAF, A375 (XREF_FIG), SK-Mel28 (XREF_FIG) and wild type BRAF, SK-Mel147 (XREF_FIG)."
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"Furthermore, we found that Usp9x KD reduced the half-life of SOX2 in the presence of cycloheximide from 6 to 4 h (XREF_FIG), suggesting that in the absence of new protein translation, Usp9x can control pre-existing SOX2 levels."
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