IndraLab

Statements

BAP1 inhibits localization. 3 / 3
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"Both variants are found in several families with BAP1-TPDS and they cause loss of function (LOF) at the protein level by nearly eliminating BAP1 deubiquitinating activity, abolishing nuclear localization, or both (Fig. 5)."
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"Thus, Bap1 appears to inhibit the epigenetic function of Hdac4, at least in part, by restricting its localization to the nucleus."
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"BAP1 ( BRCA1-associated protein-1 ) is a more recently discovered deubiquitinase member of the DRED complex and knockdown of BAP1 led to increased ubiquitination of NCoR1 and reduced its localization to the beta globin locus [ 32 ] ."
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