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Apocynin inhibits NLRP3. 3 / 3
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"The immunofluorescence and western blot results demonstrated that apocynin inhibited the NLRP3 inflammasome and promoted angiogenesis at 3 days but promoted the NLRP3 inflammasome and inhibited angiogenesis at 7 and 14 days after stroke, which was mediated by regulating autophagy activation."
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"Intriguingly, delayed administration of apocynin at 24h post-injury also attenuated oxidative damage, reduced NLRP3 inflammasome activation, and promoted microglial polarization towards the M2 like phenotype following TBI in the mouse XREF_BIBR, XREF_BIBR."
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"In another study, apocynin suppressed NLRP3 inflammasome and NF-κB signaling activation in a rat model of severe acute pancreatitis and thus, exerted antiinflammatory properties, all suggesting the co[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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