IndraLab

Statements


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"Since both Grb2 and STAM1 have been implicated in neuronal survival signaling [12-14], we speculate that the neuronal cell death in the AMSH deficient brain might be caused by the lack of interaction [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"Both pathways are interrelated at different levels, for example through the interaction of STAM-binding protein (STAMBP) with growth factor receptor-bound protein 2 (Grb2) ( xref ). xref Mutations of STAMBP have been associated with enhanced RAS-MAPK and PI3K-AKT-mTOR pathways in patients with microcephaly-capillary malformation syndrome (MIC-CAP) ( xref ) xref , underscoring the importance of both signaling pathways in cell growth, proliferation, and angiogenesis."

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