IndraLab

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USP22 deubiquitinates CCNB1. 7 / 8
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"In addition, USP22 promotes cell cycle progression and proliferation of cancer cells by regulating and inducing the deubiquitination of the cyclin B1 protein [ 67 ]."
37328395
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"USP22 can inhibit the ubiquitination of CCNB1 and induce the G2/M transition of CRC cells."
38292842
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"Indeed, USP22 inhibited CCNB1 ubiquitination both in vivo and in vitro (XREF_FIG and XREF_SUPPLEMENTARY)."
27030811
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"The deubiquitinase catalytic activity of USP22 is required for CCNB1 deubiquitination because the catalytically inactive USP22 (USP22 and C185A) mutant failed to suppress CCNB1 ubiquitination without affecting its interaction with CCNB1 (XREF_SUPPLEMENTARY)."
27030811
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"USP22 deubiquitinates cyclin B1, stabilizes cyclin B1 by antagonizing proteasome mediated degradation, and promotes itaccumulation in the nucleus (Lin etal., 2015; Melo-Cardenas etal., 2016)."
28417539
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"In addition to histones, USP22 deubiquitinates TRF1, CCNB1, CCND1, and SIRT1, thereby regulating involvement in metabolism, cycling, and apoptosis."
35935969
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"[Somewhat paradoxically, a role for USP22 in M phase has been proposed based on evidence that CCNB1 is deubiquitylated by USP22 (43)]."
30224477