IndraLab

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USP8 increases the amount of OGT. 3 / 3
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"We found that depletion of USP8 markedly decreased OGT levels without influence on its mRNA abundance (Figure  5A), and the decrease could be reversed by the addition of proteasome inhibitor MG132 or overexpression wild‐type (WT) USP8, but not its catalytically inactive mutant (USP8‐C786A) (Figure 5B,C)."
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"USP8 depletion obviously decreased OGT expression, and the reduced expression of OGT could be reversed by the re-expression of wild-type USP8 (Fig. 3H)."
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"Besides, western blotting analysis revealed that knockdown of USP8 dramatically reduced OGT protein levels (Fig. 3D)."
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