IndraLab

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USP18 inhibits CGAS. 3 / 3
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"Given that interference with USP18 decreased the protein level of cGAS ( Fig. 3 A), we speculated that USP18 might be related to the ubiquitinated degradation of cGAS."
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"Mechanistically , USP18 reduced cGAS degradation by decreasing its K48-linked ubiquitination to promote IAV-induced cGAS-STING pathway activation ."
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"Consistent with our siRNA data implicating the cGAS pathway, the relative expression of ISGs Usp18, Isg15, and Cxcl10 was markedly reduced in the absence of STING (Fig. 2B), with this effect being more pronounced in CLPP-KO/IFNAR-KO MEFs."
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