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"Indeed, Dub colonization exerted an even greater protective effect against DSS-induced colitis than Akk, with lower body weight loss (Supplementary Fig. 2c), longer colon length (Fig. 2a and Supplementary Fig. 2d), lower histopathological score (Fig. 2b, c) and less colonic macrophage infiltration (Fig. 2c)."
reach
"Treg depletion in Foxp3-DTR mice reversed the differences observed between Veh-treated (WT-Veh) and Dub-colonized WT mice (WT-Dub) in disease phenotypes (Fig. 3d and Supplementary Fig. 4j), histological evaluation (Fig. 3e, f) and proinflammatory cytokine expression (Supplementary Fig. 4k), indicating that Foxp3 Tregs are essential for the Dub protective effect against DSS-induced colitis."
reach
"Lastly, we are making great efforts to generate a mutant Dub strain with dapF (encodes essential diaminopimelate epimerase for Lys biosynthesis) depletion, which will enable us to mechanistically dissect the specific role of Dub-synthesized Lys for mitigating DSS-induced colitis.In summary, our comprehensive analysis demonstrates a previously unrevealed role of Dub in activating the AhR-IDO1-Kyn circuit in DCs, which improved the unbalanced Treg/Th17 response to ameliorate both mucosal and systemic inflammation in DSS-induced colitis."