IndraLab

Statements

USP13 increases the amount of FN1. 5 / 5
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"It has been shown that USP13 knockout reduced fibronectin expression in lungs."
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"Our previous study showed that USP13 reduction decreased fibronectin expression in lung fibroblast cells [18]."
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"We have shown that USP13 knockout reduced fibronectin expression in lungs."
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"Overexpression of USP13 increased FN and Smad4 protein levels in lung fibroblasts, while downregulation of USP13 reduced Smad4 protein levels, without altering Smad4 mRNA expression, suggesting that USP13 regulates Smad4 protein stability."
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"Though TXNIP has an anti-TGF-β1 signaling effect in lung cells, USP13 has been shown to increase FN levels by stabilizing Smad4 [35], suggesting that the effect of USP13 on TGF-β1 signaling is complex."
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