IndraLab

Statements

Capsaicin inhibits KCNH2. 3 / 3
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"XREF_BIBR found that capsaicin, a pungent irritant occurring in peppers, enhances hERG block upon mutation of Y652A 4-fold, while F656 was suggested to be relatively unimportant for block."
22194911
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"The results show that capsaicin blocks WT hERG in a concentration dependent manner, with an IC (50) of 17.45 microM and a negative shift in the steady-state inactivation curve."
19903464
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"In conclusion, capsaicin blocks hERG channels by binding to both the closed and open channel states.Y652 was important as a molecular determinant of blockade."
19903464