IndraLab

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COPS5 bound to JUN activates DNA-templated transcription. 2 / 2
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"The Jun activation-domain binding protein 1 (Jab1) is initially identified as a coactivator of activator protein (AP-1) transcription factor and found a component of the COP9 signalosome (CSN) complex, contained modulating signal transduction, gene transcription, and protein stability."
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"Furthermore, JAB1, a transcriptional coactivator that increases the specificity of AP-1 transcription factors, interacts with both c-Jun and JunD to potentiate transcription (Claret et al., 1996)."
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