IndraLab

Statements

UCHL1 activates mTORC2. 5 / 5
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"The ubiquitin hydrolase UCHL1 and PINK-1 proteins both activate mTORC2, predicting improved cell survival [ xref , xref ]."
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"Consistently, in C2C12 cells, UCHL1 knockdown increased the myotube size, enhanced mTORC1 activity, and reduced mTORC2 activities as compared with control cells."
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"Consistently , in C2C12 cells , UCHL1 knockdown increased the myotube size , enhanced mTORC1 activity , and reduced mTORC2 activities as compared with control cells ."
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"Consistently, in C2C12 cells, UCHL1 knockdown increased the myotube size, enhanced mTORC1 activity, and reduced mTORC2 activities as compared with control cells."
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"Overall , these results suggest that UCHL1 elicits a negative effect on mTORC1 and a positive effect on mTORC2 activity in slow twitch skeletal muscle ."
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