IndraLab

Statements

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"Additionally, USP3 promotes GC cell migration and invasion by positively regulating the EMT process."
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"52 Overall, USP3 primarily functions as a tumor promoter in GC, driving GC cell proliferation, invasion, migration, and the EMT process.Ubiquitin‐specific protease 3 has also been implicated in esophageal squamous cell carcinoma (ESCC)."
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"27 , 28 Recent studies have proven that USP3 promotes GBM progress by regulating the EMT process."
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"Moreover, TGF-beta1 induced USP3 expression, and USP3 knockdown inhibited TGF-beta1-induced EMT."
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"In GBM, the transcription factor Snail plays a crucial role in USP3-mediated EMT, promoting cell invasion, migration, and tumor progression [45]."
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"For example, USP3, USP11, and USP29 stimulate EMT in glioblastoma cells, as well as in ovarian or gastric cancer cells, respectively, by stabilizing Snail [80–82] ."
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"Previous studies have shown that USP3 raised GBM progression by regulating EMT."
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"However, USP3 has been demonstrated to promote EMT and tumourigenesis in glioblastoma in vitro and in vivo ( Fan et al. 2019 )."
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