IndraLab

Statements

USP4 activates Interferon. 2 / 2
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"We found that USP4 promoted the suppressive function of Treg cells by stabilizing interferon regulatory factor (IRF)8. USP4 interacts with and stabilizes IRF8 by deubiquitination of K48-linked polyubi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Congruently, the overexpression of USP4 or USP17 significantly promotes virus-induced IFN production and thereby restricts virus replication, whereas the knockdown of USP4 or USP17 has the opposite effect (77, 87)."
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