IndraLab

Statements

USP4 inhibits TGFB. 2 / 2
| 2
reach
"In this context, to achieve a certain biological outcome, the same DUB can regulate the pathway at different levels (e.g., USP15 and USP4 promote signaling by targeting the TGF-beta receptor and the effector SMADs) or multiple DUBs can act on the same target (e.g., USP15 and OTUB1 promote signaling through stabilizing R-SMADs)."
33335288
reach
"H19 functions as a competing endogenous RNA (ceRNA) by sponging miR-148a and maintaining the expression levels of ubiquitin specific protease 4 (USP4), a key miR-148a target that stabilizes TGFbetaRI and promotes TGF-beta signalling."
33732324