IndraLab

Statements

BAP1 inhibits H3K27Me3. 3 / 3
| 3
reach
"Additionally, reconstitution of BAP1 into the BAP1-KO cells downregulated H3K27me3 and EZH2 (Fig. 2c), suggesting that BAP1 loss might upregulate H3K27me3 and EZH2 and activate their downstream signaling.A recent study indicated that BAP1 is localized in the endoplasmic reticulum (ER) and bound to the type 3 inositol 1, 4, and 5-triphosphate receptor (IP3R3) [22]."
37479714
reach
"Loss of BAP1 increased the intensity of both H2AK119Ub and H3K27me3, and repressed the majority of DEG (66.2% downregulated vs. 33.8% upregulated, Fig. 6d)."
32541668
reach
"LaFave et al. demonstrated that a loss of BAP1 increases the trimethylated histone H3 lysine 27 (H3K27me3) and enhancer of zeste 2 polycomb repressive complex 2 subunits (EZH2) levels [21]."
37479714