IndraLab

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SCN5A binds NEDD4L. 4 / 10
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"Furthermore, in conditions like heart failure, elevated [Ca ] increased Nedd4-2, interaction between Nedd4-2 and Nav1.5, and Na 1.5 ubiquitination with consequent degradation , suggesting a crucial role of Nedd4-2 in Na 1.5 downregulation in heart disease."
37333254
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"F-associated transcript 10 (FAT10) repressed the interaction of NEDD4–2 and Nav1.5, resulting in protection of Nav1.5 neddylation and degradation, contributing to protection of ischemia-mediated ventr[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
36872193
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"Hyperglycemia increases the O-GlcNAcylation of Nav1.5 and reduces the interaction between Nav1.5 and Nedd4-2/SAP-97, leading to the abnormal expression and distribution of Nav1.5, loss of sodium channel function and prolongation of the PR/QT interval."
38790676
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"We found that hyperglycemia could increase the O-GlcNAc modification of Nav1.5 and inhibited the interaction between Nav1.5 and Nedd4-2/SAP-97, eventually leading to the abnormal expression and distri[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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