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USP9X deubiquitinates ALDH1A3. 4 / 4
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"For example, Chen et al. reported that USP9X could deubiquitinate ALDH1A3 in glioblastoma22."
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"USP9X deubiquitinates ALDH1A3 and maintains mesenchymal identity in glioblastoma stem cells."
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"ALDH1A3 levels are also dysregulated at the protein level in glioma stem cells, where ubiquitin-specific protease 9X (USP9X) deubiquitinates ALDH1A3, leading to its increased stabilization and levels [82]."
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"Collectively, our findings unveil <span class="match term0">USP9X</span> as a key deubiquitinase for <span class="match term1">ALDH1A3</span> protein stabilization and a potential target for GSC-directed therapy."
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