IndraLab

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ERK phosphorylates USP21. 4 / 4
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rlimsp
"Then, we analysed potential ERK phosphorylation motifs in USP21 by using Scansite (www.scansite.mit.edu) and found that USP21 contains three putative sites with the consensus ERK phosphorylation motifs XXpS/pTP (S93, S335 and S539), with S539 conserved in mice, rats and humans (Fig. 5e)."
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rlimsp
"At the post-translational level, USP21 was phosphorylated by ERKs induced by differentiation cues."
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rlimsp
"At the post-translational level, USP21 was phosphorylated by ERKs induced by differentiation cues. This phosphorylation reduced the binding of USP21 to Nanog and led to Nanog degradation."
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rlimsp
"Interestingly, we also noticed that co-expression of MEK1CA and ERK resulted in the band shift of both Nanog and USP21 (Supplementary Fig. 5b), which is possibly caused by the phosphorylation of Nanog and USP21 by the activated ERK."
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