IndraLab

Statements

ATXN3 inhibits GEMIN4. 7 / 7
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"It implies that polyQ expanded Atx3 impairs the function of P97 complex that is capable of down-regulating the neddylation level in cells."
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"However, in the pellet fractions, Atx3 100Q sequestered more P97 molecules into aggregates than Atx3 22Q, due to an increasing amount of Atx3 100Q in the pellet (XREF_FIG)."
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"However, aggregation of Atx3 100Q could sequester more endogenous P97 than that of Atx3 22Q (XREF_FIG)."
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"We have found that aggregation of polyQ expanded Atx3 can sequester P97 and Ub conjugates into the protein aggregates or inclusions through specific interactions both in vitro and in cells."
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"These results demonstrate that polyQ expanded Atx3 sequesters P97 molecules into insoluble aggregates or inclusions, which is dependent on the specific interaction via the VBM motif of Atx3."
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"PolyQ expanded Atx3 sequesters P97 to aggregates through specific interaction."
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"Because polyQ expanded Atx3 can sequester endogenous P97 into insoluble aggregates, we resorted to the previously established experiment to explore whether aggregation of Atx3 interferes with the function of P97."
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