IndraLab

Statements

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"The KCNMA1 channel blocker iberiotoxin decreases the proliferation of HeLa cervical cancer cells."
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"BK channel antagonist TEA has been reported to inhibit cell proliferation, for example, preventing mitogen stimulated quiescent lymphocytes from becoming rapidly cycling tumor cells."
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"Paxilline, a BK channel blocker, promoted cell migration and proliferation in parental GBM cells."
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"The bisphosonates Zoledronic acid used in the osteoporosis associated with bone metastasis and the BKCa channel opener NS1619, induced apoptosis through the opening of BKCa channels, while hslo gene silencing or channel blockers induced cell proliferation."
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"Blocking KCa1.1 in normal myoblasts induced an increase in proliferation, similar to that observed with DM1 myoblasts, whereas overexpression of full-length KCa1.1 alpha in DM1 myoblasts reduced their proliferation to levels observed in normal myoblasts."
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"Evidence indicates that iberiotoxin inhibits cell proliferation , migration , and invasion in breast and endometrial cancer cell lines , due to its blocking effects on BK channels ( Schickling et al ., 2015 ; Li et al ., 2018 ) ; while charybdotoxin , a known blocker of KCa3.1 , KV1.3 , and BK channels , inhibits proliferation and cell cycle progression in pancreatic and endometrial cancer cell lines ( Jager et al ., 2004 ; Schickling et al ., 2015 ; Li et al ., 2018 ) ."
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"We found that knockdown of KCNMA1 by siRNA and specific BK channel blockade by iberiotoxin inhibited cell proliferation of the prostate cancer cell line PC3, which carries an amplification of KCNMA1."
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