IndraLab

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Mutated ATXN3 leads to the deubiquitination of CHEK1. 1 / 1

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"Additionally, deubiquitinating enzyme activity of ATX3 is indispensible for its role in stabilizing Chk1, as catalytic inactive mutant of ATX3, ATX3-C14A, fails to reverse these two E3 ligase mediated polyubiquitination and degradation of Chk1, indicating a direct involvement of ATX3 in Chk1 turnover."

28180282

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IndraLab

Statements

Mutated ATXN3 leads to the deubiquitination of CHEK1. 1 / 1

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