IndraLab

Statements

CYP27A1 inhibits KCNMA1. 4 / 4
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"The responses to the known BK channel blockers CTX and TEA also support the idea that the large K + -permeable channel in F. hepatica is a member of the BK channels.The most salient finding in this st[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Under BK channel blockade by CTx, the spike frequencies in neurons from 15-Hz-TMS-treated 3xTg mice were no longer significantly different than in neurons from the sham TMS group with any current inte[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Then, the BK channel suppression in the FC group was confirmed by demonstrating that the effect of the BK channel blocker CTx was occluded in neurons from the FC group (FC + CTx, 1.46 ± 0.03 ms, N = 3[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Early experiments with CTX inhibition of the BK channel revealed that CTX binds to the extracellular surface of the channel with a 1:1 channel:toxin stoichiometry, that both the open and closed states of the channel are competent for toxin binding, and that electrostatic interactions play an important role in enhancing the toxin’s affinity ( xref )."
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