IndraLab

Statements

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"Interestingly, our data showed that USP22 promotes the proliferation but inhibits the differentiation of NSCs in the dentate gyrus (DG)of the hippocampus soon after TBI."
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"Another study in mice showed that Usp22 negatively regulates neuronal differentiation in the mouse developing brain."
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"On the contrary, depletion of USP22 delays Hes1 oscillation and thereby, induces neuronal differentiation from neuronal progenitor stem cells ."
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"Moreover, USP22 depletion promotes the differentiation of NSCs, both in vitro and in vivo."
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"In contrast, USP22 overexpression inhibits NSC differentiation into neurons."
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"For instance, two histone directed DUBs, USP44 and USP22, are antagonistically regulated in their mRNA expression to ensure faithful stem cell differentiation [XREF_BIBR - XREF_BIBR]."
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