IndraLab
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"Some evidence suggests that FHF1 does not bind to the C-terminus of Nav1.1 channels [ xref ], but the highly conserved cores of FHF2A (also referred to as FGF13S), FHF3A, and FHF4B were shown to bind the C-terminal domain (CTD) of Na v 1.1 using a biosensor chip analysis [ xref ]."
"Sodium channel fast inactivation is modulated by alpha subunit interaction with a family of cytoplasmic proteins termed fibroblast growth factor homologous factors (FHFs). In this paper, we report that all A-type FHFs exert rapid onset long-term inactivation on Nav1.6 and other sodium channels."