IndraLab

Statements

USP45 deubiquitinates CORO1B. 3 / 3
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"USP45 interacted with and deubiquitinated the actin-regulatory protein Coronin 1B (Coro1B) to promote actin turnover."
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"Moreover, expression of USP45-WT, but not the catalytically inactive USP45 (C199A) mutant, dramatically decreased the ubiquitination of Coro1B under both mild (1% Triton) and denaturing (1% SDS) conditions (Fig. 5, K and L; and Fig. S3 D), suggesting that USP45 protease activity is required for the deubiquitination of Coro1B."
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"Since USP45 mediates Coro1B deubiquitination and regulates its stability, we investigated whether USP45 might regulate actin dynamics by targeting Coro1B."
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