IndraLab

Statements

CYLD inhibits CTNNB1. 5 / 5
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"Loss of CYLD in HMCLs was found to enhance β-catenin stabilization and localization to the nucleus, increase β-catenin-LEF/TCF reporter activity, and enhance MM cell growth and survival."
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"In human cylindroma, CYLD negatively regulates Wnt and beta-catenin signaling via deubiquitination of Dishevelled, which is a key component in Wnt mediated beta-catenin nuclear translocation."
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"It was also reported that loss of CYLD enhances Wnt/beta-catenin signaling through the K63-linked ubiquitination of Dvl ( Tauriello et al., 2010 )."
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"Increased CYLD expression may likewise diminish Wnt pathway activation and beta-catenin accumulation (XREF_FIG) via K63 linked deubiquitination of Dvl."
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"In the Wnt signal transduction pathway, CYLD inhibits beta-catenin signaling by removing Lysine 63 linked ubiquitination from Dishevelled."
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