IndraLab

Statements

CYLD inhibits CTNNB1. 4 / 4
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"In the Wnt signal transduction pathway, CYLD inhibits beta-catenin signaling by removing Lysine 63 linked ubiquitination from Dishevelled."
24756567
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"In human cylindroma, CYLD negatively regulates Wnt and beta-catenin signaling via deubiquitination of Dishevelled, which is a key component in Wnt mediated beta-catenin nuclear translocation."
22235375
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"Increased CYLD expression may likewise diminish Wnt pathway activation and beta-catenin accumulation (XREF_FIG) via K63 linked deubiquitination of Dvl."
23034333
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"Loss of CYLD in HMCLs was found to enhance β-catenin stabilization and localization to the nucleus, increase β-catenin-LEF/TCF reporter activity, and enhance MM cell growth and survival."
29776381